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中华肝脏外科手术学电子杂志 ›› 2021, Vol. 10 ›› Issue (05) : 489 -492. doi: 10.3877/cma.j.issn.2095-3232.2021.05.012

临床研究

双层探测器光谱CT低keV虚拟单能级图像在小肝癌评估中的应用
骆秋霞1, 李远辉1, 张建生1, 汤朝晖1, 谢倩玮1, 何炳均1,()   
  1. 1. 广州 510630,中山大学附属第三医院放射科
  • 收稿日期:2021-06-02 出版日期:2021-08-17
  • 通信作者: 何炳均

Application of dual-layer spectral detector CT with low kiloelectron volt virtual monoenergetic imaging in evaluation of small liver cancer

Qiuxia Luo1, Yuanhui Li1, Jiansheng Zhang1, Zhaohui Tang1, Qianwei Xie1, Bingjun He1,()   

  1. 1. Department of Radiology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China
  • Received:2021-06-02 Published:2021-08-17
  • Corresponding author: Bingjun He
引用本文:

骆秋霞, 李远辉, 张建生, 汤朝晖, 谢倩玮, 何炳均. 双层探测器光谱CT低keV虚拟单能级图像在小肝癌评估中的应用[J]. 中华肝脏外科手术学电子杂志, 2021, 10(05): 489-492.

Qiuxia Luo, Yuanhui Li, Jiansheng Zhang, Zhaohui Tang, Qianwei Xie, Bingjun He. Application of dual-layer spectral detector CT with low kiloelectron volt virtual monoenergetic imaging in evaluation of small liver cancer[J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2021, 10(05): 489-492.

目的

探讨双层探测器光谱CT(DLCT)低千电子伏特(keV)虚拟单能级图像(VMI)重建在小肝癌评估中的价值。

方法

回顾性分析2020年3月至2021年2月中山大学附属第三医院采用DLCT行肝胆胰脾增强扫描的28例小肝癌患者临床影像资料。其中男24例,女4例;年龄29~67岁,中位年龄55岁。患者均签署知情同意书,符合医学伦理学规定。术前1周行DLCT检查,利用后处理工作站将全息光谱图像数据包分解及整合重建,患者图像分为常规CT图像组(CI组)、40 keV虚拟单能级图像组(VMI40组)、50 keV虚拟单能级图像组(VMI50组)。CT值、信噪比(SNR)、对比噪声比(CNR)等客观评分比较采用配对样本t检验。图像的整体图像质量、图像噪声、图像锐利度、病灶显著性等主观评分比较采用Wilcoxon秩和检验。

结果

客观图像质量评估中,VMI40组病灶CT值、SNR和CNR分别为242±51、14.1±5.9、8.9±4.5,明显高于VMI50组的176±32、12.2±4.4、6.7±3.1(t=18.12,5.08,7.07;P<0.05);VMI50组CT值、SNR和CNR亦明显高于CI组的114±17、7.8±2.4、3.2±1.4(t=18.01,5.60,7.29;P<0.05)。主观图像质量分数评估中,VMI40组病灶显著性分数为5(1)分,明显高于VMI50组和CI组的4(2)、3(2) (Z=4.00,4.77;P<0.05)。

结论

与CI相比,DLCT低keV VMI可提高小肝癌病灶图像质量和检出率。

Objective

To evaluate the application of dual-layer spectral detector CT (DLCT) with low kiloelectron volt (keV) virtual monoenergetic imaging (VMI) reconstruction in the evaluation of small liver cancer.

Methods

Clinical imaging data of 28 patients with small liver cancer receiving enhanced DLCT scan of the liver, gallbladder, pancreas and spleen in the Third Affiliated Hospital of Sun Yat-sen University from March 2020 to February 2021 were retrospectively analyzed. Among them,24 patients were male and 4 female, aged from 29 to 67 years, with a median age of 55 years. The informed consents of the patients were obtained and the local ethical committee approval was received. At 1 week before operation, patients received DLCT examination. The holographic spectral imaging data packages were decomposed and reconstructed by post-processing workstation. The patients' images were divided into the conventional CT image group (CI group), 40 keV VMI group (VMI40 group) and 50 keV VMI group (VMI50 group). CT value, signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR) and other objective scores were statistically compared by paired t test. The subjective scores such as the overall image quality, image noise, image sharpness and lesion significance were compared by Wilcoxon signed rank-sum test.

Results

In the objective image quality assessment, the CT value, SNR and CNR in the VMI40 group were 242±51, 14.1±5.9 and 8.9±4.5, significantly higher than 176±32, 12.2±4.4 and 6.7±3.1 in the VMI50 group (t=18.12, 5.08, 7.07; P<0.05). The CT value, SNR and CNR in the VMI50 group were also significantly higher than 114±17, 7.8±2.4 and 3.2±1.4 in the CI group (t=18.01, 5.60, 7.29; P<0.05). In the subjective image quality evaluation, the lesion significance score in the VMI40 group was 5(1), significantly higher than 4(2) and 3(2) in the VMI50 and CI groups (Z=4.00, 4.77; P<0.05).

Conclusions

Compared with CI, DLCT with low keV VMI can improve the image quality and detection rate of small liver cancer lesions.

表1 VMI40、VMI50、CI组图像质量客观评价参数(±s
表2 VMI40、VMI50、CI组图像质量主观评价参数[M(QR)]
[1]
中华预防医学会肿瘤预防与控制专业委员会感染相关肿瘤防控学组, 中华预防医学会慢病预防与控制分会, 中华预防医学会健康传播分会. 中国肝癌一级预防专家共识(2018)[J]. 中国肿瘤, 2018, 27(9):660-669.
[2]
齐峰, 戴朝六. 微小肝癌和小肝癌诊断和治疗方式的共识和分歧[J]. 现代肿瘤医学, 2020, 28(6):1048-1052.
[3]
张汉洋, 庄志彬, 林春冬, 等. 经皮射频消融术与腹腔镜肝切除术治疗原发性小肝癌的疗效及预后比较[J]. 中国普通外科杂志, 2019, 28(1):24-30.
[4]
Yoon JH, Lee JM, Lee YJ, et al. Added value of sequentially performed gadoxetic acid-enhanced liver MRI for the diagnosis of small (10-19 mm) or atypical hepatic observations at contrast-enhanced CT: a prospective comparison[J]. J Magn Reson Imaging, 2019, 49(2):574-587.
[5]
苏泳诗, 于新发. 小肝癌临床治疗研究进展[J]. 实用肿瘤杂志, 2019, 34(2):175-179.
[6]
刘允怡, 赖俊雄. 肝癌微创介入治疗[J/OL]. 中华肝脏外科手术学电子杂志, 2020, 9(3):201-205.
[7]
Kim TM, Kim SY, Cho JY, et al. Utilization of virtual low-keV monoenergetic images generated using dual-layer spectral detector computed tomography for the assessment of peritoneal seeding from ovarian cancer[J]. Medicine, 2020, 99(23):e20444.
[8]
王世伟, 李金锋, 邹颖, 等. 双层探测器能谱CT单能级成像对门静脉成像质量的影响[J]. 中国临床医学影像杂志, 2020, 31(6): 425-428, 433.
[9]
王京艳, 刘妍, 周霖, 等. 经导管肝动脉化疗栓塞联合经皮射频消融治疗早,中期肝细胞癌的疗效及预后影响因素[J/CD]. 中国肝脏病杂志(电子版), 2020, 12(4):1-10.
[10]
Ding XX, Zhu QG, Zhang SM, et al. Precision medicine for hepatocellular carcinoma: driver mutations and targeted therapy[J]. Oncotarget, 2017, 8(33):55715-55730.
[11]
Kulik L, El-Serag HB. Epidemiology and management of hepatocellular carcinoma[J]. Gastroenterology, 2019, 156(2):477-491.
[12]
Jamali S, Michoux N, Coche E, et al. Virtual unenhanced phase with spectral dual-energy CT: is it an alternative to conventional true unenhanced phase for abdominal tissues?[J]. Diagn Interv Imaging, 2019, 100(9):503-511.
[13]
谭晶文, 朱兰, 王兰, 等. 新型双层探测器光谱CT在直肠癌术前T分期中的价值[J]. 中华放射学杂志, 2020, 54(7):671-676.
[14]
任海燕,甄艳华,郑加贺. 双层光谱探测器CT临床应用与研究进展[J]. 中国医学影像技术, 2020, 36(10):1555-1558.
[15]
徐嘉旭, 严福华, 韩群,等. 双层探测器光谱CT胰腺动态增强40 keV虚拟单能量图像优化窗口设置研究[J]. 中华放射学杂志, 2020, 54(7):665-670.
[16]
Kalisz K, Rassouli N, Dhanantwari A, et al. Noise characteristics of virtual monoenergetic images from a novel detector-based spectral CT scanner[J]. Eur J Radiol, 2018, 98:118-125.
[17]
Ghandour A, Sher A, Rassouli N, et al. Evaluation of virtual monoenergetic images on pulmonary vasculature using the dual-layer detector-based spectral computed tomography[J]. J Comput Assist Tomogr, 2018, 42(6):858-865.
[18]
Rassouli N, Etesami M, Dhanantwari A, et al. Detector-based spectral CT with a novel dual-layer technology: principles and applications[J]. Insights Imaging, 2017, 8(6):589-598.
[19]
杨琰昭, 徐嘉旭, 李若坤, 等. 双层探测器光谱CT能谱图像在胰腺神经内分泌肿瘤检出中的应用价值[J]. 中华放射学杂志, 2020, 54(6):534-538.
[20]
付志浩, 杜超, 李代欣, 等. 双层探测器能谱CT在小肝癌显示中最佳单能量选择初步研究[J]. 医学影像学杂志, 2020, 30(3):409-413.
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