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中华肝脏外科手术学电子杂志 ›› 2022, Vol. 11 ›› Issue (04) : 347 -350. doi: 10.3877/cma.j.issn.2095-3232.2022.04.005

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ALPPS临床应用及术式改良
杨雄威1, 高晓杰1, 覃日利1, 张新晨1,()   
  1. 1. 150000 哈尔滨医科大学附属第二医院普通外科
  • 收稿日期:2022-04-26 出版日期:2022-08-10
  • 通信作者: 张新晨

Clinical application and modified operation of associating liver partition and portal vein ligation for staged hepatectomy

Xiongwei Yang1, Xiaojie Gao1, Rili Qin1   

  • Received:2022-04-26 Published:2022-08-10
引用本文:

杨雄威, 高晓杰, 覃日利, 张新晨. ALPPS临床应用及术式改良[J]. 中华肝脏外科手术学电子杂志, 2022, 11(04): 347-350.

Xiongwei Yang, Xiaojie Gao, Rili Qin. Clinical application and modified operation of associating liver partition and portal vein ligation for staged hepatectomy[J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2022, 11(04): 347-350.

剩余肝体积(FLR)及其结构完整性是决定肝切除术后肝脏功能代偿状态和手术安全的关键,FLR不足引起肝切除术后肝衰竭(post-hepatectomy liver failure,PHLF),即"小体积综合征(small for size syndrome,SFSS)"常导致患者死亡。ALPPS通过在第一阶段离断病损肝脏与正常肝脏,以及结扎病损肝脏侧门静脉,促使FLR在短期内显著增大,从而可在第二阶段完整切除目标病灶的同时,确保剩余肝脏解剖结构的完整和功能性体积达到安全范围,最终使因FLR不足而无法手术治疗的患者获得手术机会。自2007年由德国的Schlitt教授首次开展以来[1],ALPPS在世界范围内引起了肝脏外科医师极大的关注并进行了大量的相关研究。

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