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中华肝脏外科手术学电子杂志 ›› 2023, Vol. 12 ›› Issue (05) : 490 -494. doi: 10.3877/cma.j.issn.2095-3232.2023.05.004

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肿瘤生物学特征在肝癌肝移植治疗中的意义
王孟龙()   
  1. 100069 北京,首都医科大学附属北京佑安医院普通外科中心暨器官移植科
  • 收稿日期:2023-07-12 出版日期:2023-10-10
  • 通信作者: 王孟龙
  • 基金资助:
    国家自然科学基金指南引导类原创探索计划项目(82150110)

Significance of biological characteristics in liver transplantation for HCC

Menglong Wang()   

  • Received:2023-07-12 Published:2023-10-10
  • Corresponding author: Menglong Wang
引用本文:

王孟龙. 肿瘤生物学特征在肝癌肝移植治疗中的意义[J]. 中华肝脏外科手术学电子杂志, 2023, 12(05): 490-494.

Menglong Wang. Significance of biological characteristics in liver transplantation for HCC[J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2023, 12(05): 490-494.

原发性肝癌是目前我国第4位常见恶性肿瘤及第2位肿瘤致死病因,其中肝细胞癌(HCC)占85%~90%[1]。85%~95%的HCC患者有肝硬化背景,每年肝硬化患者HCC发生率为2%~4%,HBV、HCV、酒精性和非酒精性脂肪肝等均是HCC的高危因素[2]。肝移植因其既解决肿瘤又解决肝硬化背景而成为HCC治疗的理想选择。中国肝移植注册中心(China Liver Transplant Registry,CLTR)数据显示,2018~2020年国内肝移植数量平均约6 000例/年,其中肝癌肝移植占比为35.0%[3]。然而,肝移植术后仍面临着肿瘤复发问题,而HCC的肿瘤生物学特征则是影响复发的主要因素[4]。因此,本文拟就其在肝移植的选择、桥接治疗与降期处理以及预后中的意义等问题进行探讨。

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