切换至 "中华医学电子期刊资源库"

中华肝脏外科手术学电子杂志 ›› 2023, Vol. 12 ›› Issue (05) : 490 -494. doi: 10.3877/cma.j.issn.2095-3232.2023.05.004

所属专题: 述评 综述

专家论坛

肿瘤生物学特征在肝癌肝移植治疗中的意义
王孟龙()   
  1. 100069 北京,首都医科大学附属北京佑安医院普通外科中心暨器官移植科
  • 收稿日期:2023-07-12 出版日期:2023-10-10
  • 通信作者: 王孟龙
  • 基金资助:
    国家自然科学基金指南引导类原创探索计划项目(82150110)

Significance of biological characteristics in liver transplantation for HCC

Menglong Wang()   

  • Received:2023-07-12 Published:2023-10-10
  • Corresponding author: Menglong Wang
引用本文:

王孟龙. 肿瘤生物学特征在肝癌肝移植治疗中的意义[J/OL]. 中华肝脏外科手术学电子杂志, 2023, 12(05): 490-494.

Menglong Wang. Significance of biological characteristics in liver transplantation for HCC[J/OL]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2023, 12(05): 490-494.

原发性肝癌是目前我国第4位常见恶性肿瘤及第2位肿瘤致死病因,其中肝细胞癌(HCC)占85%~90%[1]。85%~95%的HCC患者有肝硬化背景,每年肝硬化患者HCC发生率为2%~4%,HBV、HCV、酒精性和非酒精性脂肪肝等均是HCC的高危因素[2]。肝移植因其既解决肿瘤又解决肝硬化背景而成为HCC治疗的理想选择。中国肝移植注册中心(China Liver Transplant Registry,CLTR)数据显示,2018~2020年国内肝移植数量平均约6 000例/年,其中肝癌肝移植占比为35.0%[3]。然而,肝移植术后仍面临着肿瘤复发问题,而HCC的肿瘤生物学特征则是影响复发的主要因素[4]。因此,本文拟就其在肝移植的选择、桥接治疗与降期处理以及预后中的意义等问题进行探讨。

[1]
国家卫生健康委办公厅. 原发性肝癌诊疗指南(2022版)[J]. 临床肝胆病杂志, 2022, 38(2):288-303.
[2]
Heimbach JK, Kulik LM, Finn RS, et al. AASLD guidelines for the treatment of hepatocellular carcinoma[J]. Hepatology, 2018, 67(1): 358-380.
[3]
中国医师协会器官移植医师分会, 中华医学会器官移植学分会肝移植学组. 中国肝癌肝移植临床实践指南(2021版)[J]. 中华消化外科杂志, 2022, 21(4):433-443.
[4]
Shimamura T, Goto R, Watanabe M, et al. Liver transplantation for hepatocellular carcinoma: how should we improve the thresholds?[J]. Cancers, 2022, 14(2):419-455.
[5]
Yoneda N, Matsui O, Kobayashi S, et al. Current status of imaging biomarkers predicting the biological nature of hepatocellular carcinoma[J]. Jpn J Radiol, 2019, 37(3):191-208.
[6]
Chianchiano P, Pezhouh MK, Kim A, et al. Distinction of intrahepatic metastasis from multicentric carcinogenesis in multifocal hepatocellular carcinoma using molecular alterations[J]. Hum Pathol, 2018(72):127-134.
[7]
Cunha GM, Hosseini M, Furlan A, et al. Hepatocellular carcinoma staging: differences between radiologic and pathologic systems and relevance to patient selection and outcomes in liver transplantation[J]. AJR Am J Roentgenol, 2022, 218(1):77-86.
[8]
Pommergaard HC, Rostved AA, Adam R, et al. Vascular invasion and survival after liver transplantation for hepatocellular carcinoma: a study from the European Liver Transplant Registry[J]. HPB, 2018, 20(8):768-775.
[9]
Antwi SO, Habboush YY, Chase LA, et al. Response to loco-regional therapy predicts outcomes after liver transplantation for combined hepatocellular-cholangiocarcinoma[J]. Ann Hepatol, 2018, 17(6):969-979.
[10]
Galle PR, Foerster F, Kudo M, et al. Biology and significance of alpha-fetoprotein in hepatocellular carcinoma[J]. Liver Int, 2019, 39(12):2214-2229.
[11]
Cillo U, Giuliani T, Polacco M, et al. Prediction of hepatocellular carcinoma biological behavior in patient selection for liver transplantation[J]. World J Gastroenterol, 2016, 22(1):232-252.
[12]
Singh AK, Kumar R, Pandey AK. Hepatocellular carcinoma: causes, mechanism of progression and biomarkers[J]. Curr Chem Genom Transl Med, 2018(12):9-26.
[13]
Najjar M, Agrawal S, Emond JC, et al. Pretreatment neutrophil-lymphocyte ratio: useful prognostic biomarker in hepatocellular carcinoma[J]. J Hepatocell Carcinoma, 2018(5):17-28.
[14]
Torizuka T, Tamaki N, Inokuma T, et al. In vivo assessment of glucose metabolism in hepatocellular carcinoma with FDG-PET[J].J Nucl Med, 1995, 36(10):1811-1817.
[15]
Hong G, Suh KS, Suh SW, et al. Alpha-fetoprotein and (18)F-FDG positron emission tomography predict tumor recurrence better than Milan criteria in living donor liver transplantation[J]. J Hepatol, 2016, 64(4):852-859.
[16]
Lai Q, Avolio AW, Graziadei I, et al. Alpha-fetoprotein and modified response evaluation criteria in solid tumors progression after locoregional therapy as predictors of hepatocellular cancer recurrence and death after transplantation[J]. Liver Transpl, 2013, 19(10):1108-1118.
[17]
Halazun KJ, Sapisochin G, von Ahrens D, et al. Predictors of outcome after liver transplantation for hepatocellular carcinoma (HCC) beyond Milan criteria[J]. Int J Surg, 2020(82S):61-69.
[18]
Mazzaferro V, Llovet JM, Miceli R, et al. Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: a retrospective, exploratory analysis[J]. Lancet Oncol, 2009, 10(1):35-43.
[19]
Yao FY, Ferrell L, Bass NM, et al. Liver transplantation for hepatocellular carcinoma: expansion of the tumor size limits does not adversely impact survival[J]. Hepatology, 2001, 33(6):1394-1403.
[20]
Kamarajah SK, Frankel TL, Sonnenday C, et al. Critical evaluation of the American Joint Commission on Cancer (AJCC) 8th edition staging system for patients with hepatocellular carcinoma (HCC):a surveillance, epidemiology, end results (SEER) analysis[J]. J Surg Oncol, 2018, 117(4):644-650.
[21]
Reig M, Forner A, Rimola J, et al. BCLC strategy for prognosis prediction and treatment recommendation: the 2022 update[J]. J Hepatol, 2022, 76(3):681-693.
[22]
Crocetti L, Bozzi E, Scalise P, et al. Locoregional treatments for bridging and downstaging HCC to liver transplantation[J]. Cancers, 2021, 13(21):5558.
[23]
Biolato M, Galasso T, Marrone G, et al. Upper limits of downstaging for hepatocellular carcinoma in liver transplantation[J]. Cancers, 2021, 13(24):6337.
[24]
Yao FY, Mehta N, Flemming J, et al. Downstaging of hepatocellular cancer before liver transplant: long-term outcome compared to tumors within Milan criteria[J]. Hepatology, 2015, 61(6):1968-1977.
[25]
Gao Q, Anwar IJ, Abraham N, et al. Liver transplantation for hepatocellular carcinoma after downstaging or bridging therapy with immune checkpoint inhibitors[J]. Cancers, 2021, 13(24):6307.
[26]
Mehta N, Guy J, Frenette CT, et al. Excellent outcomes of liver transplantation following down-staging of hepatocellular carcinoma to within Milan criteria: a multicenter study[J]. Clin Gastroenterol Hepatol, 2018, 16(6):955-964.
[27]
Sinha J, Mehta N, Dodge JL, et al. Are there upper limits in tumor burden for down-staging of hepatocellular carcinoma to liver transplant? analysis of the all-comers protocol[J]. Hepatology, 2019, 70(4):1185-1196.
[28]
Vitale A, Volk M, Cillo U. Transplant benefit for patients with hepatocellular carcinoma[J]. World J Gastroenterol, 2013, 19(48):9183-9188.
[29]
Kanneganti M, Mahmud N, Kaplan DE, et al. Survival benefit of liver transplantation for hepatocellular carcinoma[J]. Transplantation, 2020, 104(1):104-112.
[30]
Zheng S, Xie Q, Cheng J. Salvage liver transplant for hepatocellular carcinoma: rescues and benefits[J]. Transl Gastroenterol Hepatol, 2018(3):65.
[31]
Lai Q, Vitale A, Iesari S, et al. Intention-to-treat survival benefit of liver transplantation in patients with hepatocellular cancer[J]. Hepatology, 2017, 66(6):1910-1919.
[32]
Sasaki K, Firl DJ, Hashimoto K, et al. Development and validation of the HALT-HCC score to predict mortality in liver transplant recipients with hepatocellular carcinoma: a retrospective cohort analysis[J]. Lancet Gastroenterol Hepatol, 2017, 2(8):595-603.
[33]
Firl DJ, Sasaki K, Agopian VG, et al. Charting the path forward for risk prediction in liver transplant for hepatocellular carcinoma: international validation of HALTHCC among 4,089 patients[J]. Hepatology, 2020, 71(2):569-582.
[1] 杨桂清, 孟静静. 哺乳期亚临床乳腺炎的研究进展[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 376-379.
[2] 李华志, 曹广, 刘殿刚, 张雅静. 不同入路下行肝切除术治疗原发性肝细胞癌的临床对比[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 52-55.
[3] 常小伟, 蔡瑜, 赵志勇, 张伟. 高强度聚焦超声消融术联合肝动脉化疗栓塞术治疗原发性肝细胞癌的效果及安全性分析[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 56-59.
[4] 屈翔宇, 张懿刚, 李浩令, 邱天, 谈燚. USP24及其共表达肿瘤代谢基因在肝细胞癌中的诊断和预后预测作用[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 659-662.
[5] 付成旺, 杨大刚, 王榕, 李福堂. 营养与炎症指标在可切除胰腺癌中的研究进展[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 704-708.
[6] 傅斌生, 冯啸, 杨卿, 曾凯宁, 姚嘉, 唐晖, 刘剑戎, 魏绪霞, 易慧敏, 易述红, 陈规划, 杨扬. 脂肪变性供肝在成人劈离式肝移植中的应用[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 789-794.
[7] 中华医学会器官移植学分会. 肝移植术后缺血性胆道病变诊断与治疗中国实践指南[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 739-748.
[8] 公宇, 廖媛, 尚梅. 肝细胞癌TACE术后复发影响因素及预测模型建立[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 818-824.
[9] 李一帆, 朱帝文, 任伟新, 鲍应军, 顾俊鹏, 张海潇, 曹耿飞, 阿斯哈尔·哈斯木, 纪卫政. 血GP73水平在原发性肝癌TACE疗效评价中的作用[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 825-830.
[10] 刘敏思, 李荣, 李媚. 基于GGT与Plt比值的模型在HBV相关肝细胞癌诊断中的作用[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 831-835.
[11] 魏志鸿, 刘建勇, 吴小雅, 杨芳, 吕立志, 江艺, 蔡秋程. 肝移植术后急性移植物抗宿主病的诊治(附四例报告)[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 846-851.
[12] 焦振东, 惠鹏, 金上博. 三维可视化结合ICG显像技术在腹腔镜肝切除术治疗复发性肝癌中的应用[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 859-864.
[13] 陈晓鹏, 王佳妮, 练庆海, 杨九妹. 肝细胞癌VOPP1表达及其与预后的关系[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 876-882.
[14] 袁雨涵, 杨盛力. 体液和组织蛋白质组学分析在肝癌早期分子诊断中的研究进展[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 883-888.
[15] 王子阳, 王宏宾, 刘晓旌. 血清标志物对甲胎蛋白阴性肝细胞癌诊断的研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(07): 677-681.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?