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中华肝脏外科手术学电子杂志 ›› 2024, Vol. 13 ›› Issue (03) : 389 -393. doi: 10.3877/cma.j.issn.2095-3232.2024.03.022

所属专题: 综述

综述

外周血cfDNA液体活检技术在肝棘球蚴病诊治中的应用进展
杨智義1, 赵成俊1, 胡欣芫1, 潘佰猛1, 张秋雨1, 张挽乾1, 曹芮1, 张灵强1,()   
  1. 1. 810000 西宁,青海大学附属医院肝胆胰外科
  • 收稿日期:2024-02-09 出版日期:2024-06-10
  • 通信作者: 张灵强
  • 基金资助:
    中科院兰州分院"西部之光"项目

Application of peripheral blood cfDNA liquid biopsy in diagnosis and treatment of hepatic echinococcosis

Zhiyi Yang1, Chengjun Zhao1, Xinyuan Hu1, Baimeng Pan1, Qiuyu Zhang1, Wanqian Zhang1, Rui Cao1, Lingqiang Zhang1,()   

  1. 1. Department of Hepatobiliary and Pancreatic Surgery, Qinghai University Affiliated Hospital, Xining 810000, China
  • Received:2024-02-09 Published:2024-06-10
  • Corresponding author: Lingqiang Zhang
引用本文:

杨智義, 赵成俊, 胡欣芫, 潘佰猛, 张秋雨, 张挽乾, 曹芮, 张灵强. 外周血cfDNA液体活检技术在肝棘球蚴病诊治中的应用进展[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(03): 389-393.

Zhiyi Yang, Chengjun Zhao, Xinyuan Hu, Baimeng Pan, Qiuyu Zhang, Wanqian Zhang, Rui Cao, Lingqiang Zhang. Application of peripheral blood cfDNA liquid biopsy in diagnosis and treatment of hepatic echinococcosis[J/OL]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2024, 13(03): 389-393.

循环游离DNA(cfDNA)是主要存在于血液以及其他体液的核酸片段,包括细胞核DNA和线粒体DNA。cfDNA作为一种"液体活检"技术,在肝棘球蚴病的诊断、预后和疗效监测等方面均有重要的应用价值,有望成为新一代的肝棘球蚴病诊治新方法。

Circulating cell-free DNA (cfDNA) is a nucleic acid fragment mainly existing in blood and other body fluids, including nuclear DNA and mitochondrial DNA. As a "liquid biopsy" technique, cfDNA has high application value in the diagnosis, prognosis and clinical efficacy monitoring of hepatic echinococcosis, which is expected to become a new-generation diagnosis and treatment approach for hepatic echinococcosis.

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