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中华肝脏外科手术学电子杂志 ›› 2024, Vol. 13 ›› Issue (03) : 394 -397. doi: 10.3877/cma.j.issn.2095-3232.2024.03.023

综述

肝脏缺血-再灌注损伤与cGAS-STING信号通路
阿卜杜萨拉木·图尔荪麦麦提1, 吐尔洪江·吐逊1, 温浩1,()   
  1. 1. 830054 乌鲁木齐,新疆医科大学第一附属医院消化血管外科中心 肝脏·腹腔镜外科
  • 收稿日期:2024-01-15 出版日期:2024-06-10
  • 通信作者: 温浩
  • 基金资助:
    国家自然科学基金(82260411,82270632); 新疆维吾尔自治区科技厅重点实验室开放课题项目(2018D04002)

Liver ischemia-reperfusion injury and cGAS-STING signaling pathway

Tuersunmaimaiti Abudusalamu·1, Tuxun Tuerhongjiang·1, Hao Wen1,()   

  1. 1. Department of Liver and Laparoscopic Surgery, Digestive Vascular Surgery Center, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
  • Received:2024-01-15 Published:2024-06-10
  • Corresponding author: Hao Wen
引用本文:

阿卜杜萨拉木·图尔荪麦麦提, 吐尔洪江·吐逊, 温浩. 肝脏缺血-再灌注损伤与cGAS-STING信号通路[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(03): 394-397.

Tuersunmaimaiti Abudusalamu·, Tuxun Tuerhongjiang·, Hao Wen. Liver ischemia-reperfusion injury and cGAS-STING signaling pathway[J/OL]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2024, 13(03): 394-397.

肝脏缺血-再灌注损伤(IRI)通常发生在肝脏手术(肝移植、肝切除)以及各种循环休克事件中,是术后肝功能不全、疾病转归及患者预后不良等不可避免的临床问题。环磷酸鸟苷-磷酸腺苷合成酶(cGAS)是近些年来新发现的关键DNA受体,是一种感应细胞内DNA损伤的酶,当细胞内DNA受损时,会被激活cGAS-STING信号通路并产生相关免疫因子,诱导机体炎症免疫激活,推动炎症性肝细胞损伤。本文就cGAS-STING信号通路的激活过程及其在肝脏IRI中相关作用与机制展开综述。

Liver ischemia-reperfusion injury (IRI) mainly occurs in liver surgery (liver transplantation, hepatectomy) and multiple circulatory shock events, which is an inevitable clinical problem for postoperative liver dysfunction, disease outcome and poor prognosis of patients, etc. As a newly-discovered key DNA receptor in recent years, cyclic GMP-AMP synthase (cGAS) is an endogenous DNA sensor. When intracellular DNA damage occurs, cGAS-STING signaling pathway will be activated and relevant immune cytokines will be generated, which will induce inflammatory immune activation and aggravate inflammatory hepatocyte damage. In this article, the activation process of cGAS-STING signaling pathway and its role and mechanism in liver IRI were reviewed.

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