| [1] |
Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2024, 74(3): 229-263.DOI: 10.3322/caac.21834.
|
| [2] |
滕熠, 张晓丹, 夏昌发, 等. 中国与全球癌症发病、死亡和患病对比及其预测分析: GLOBOCAN 2022数据解读[J]. 中华肿瘤防治杂志, 2024, 31(23): 1413-1420.
|
| [3] |
Singal AG, Llovet JM, Yarchoan M, et al. AASLD Practice Guidance on prevention, diagnosis, and treatment of hepatocellular carcinoma[J]. Hepatology, 2023, 78(6): 1922-1965.DOI: 10.1097/HEP.0000000000000466.
|
| [4] |
|
| [5] |
Coffman-D'Annibale K, Xie C, Hrones DM, et al. The current landscape of therapies for hepatocellular carcinoma[J]. Carcinogenesis, 2023, 44(7): 537-548.DOI: 10.1093/carcin/bgad052.
|
| [6] |
|
| [7] |
Granata V, Fusco R, Setola SV, et al. An update on radiomics techniques in primary liver cancers[J]. Infect Agent Cancer, 2022, 17(1): 6.DOI: 10.1186/s13027-022-00422-6.
|
| [8] |
Bo Z, Song J, He Q, et al. Application of artificial intelligence radiomics in the diagnosis, treatment, and prognosis of hepatocellular carcinoma[J]. Comput Biol Med, 2024, 173: 108337.DOI: 10.1016/j.compbiomed.2024.108337.
|
| [9] |
McCague C, Ramlee S, Reinius M, et al. Introduction to radiomics for a clinical audience[J]. Clin Radiol, 2023, 78(2): 83-98.DOI: 10.1016/j.crad.2022.08.149.
|
| [10] |
Avery E, Sanelli PC, Aboian M, et al. Radiomics: a primer on processing workflow and analysis[J]. Semin Ultrasound CT MR, 2022, 43(2): 142-146.DOI: 10.1053/j.sult.2022.02.003.
|
| [11] |
|
| [12] |
Zhang W, Guo Y, Jin Q. Radiomics and its feature selection: a review[J]. Symmetry, 2023, 15(10): 1834.DOI: 10.3390/sym15101834.
|
| [13] |
Avanzo M, Wei L, Stancanello J, et al. Machine and deep learning methods for radiomics[J]. Med Phys, 2020, 47(5): e185-e202.DOI: 10.1002/mp.13678.
|
| [14] |
Demircioğlu A. Are deep models in radiomics performing better than generic models? A systematic review[J]. Eur Radiol Exp, 2023, 7(1): 11.DOI: 10.1186/s41747-023-00325-0.
|
| [15] |
Jiang C, Cai YQ, Yang JJ, et al. Radiomics in the diagnosis and treatment of hepatocellular carcinoma[J]. Hepatobiliary Pancreat Dis Int, 2023, 22(4): 346-351.DOI: 10.1016/j.hbpd.2023.03.010.
|
| [16] |
Fusco R, Granata V, Setola SV, et al. The application of radiomics in cancer imaging with a focus on lung cancer, renal cell carcinoma, gastrointestinal cancer, and head and neck cancer: a systematic review[J]. Phys Med, 2025, 130: 104891.DOI: 10.1016/j.ejmp.2025.104891.
|
| [17] |
Harding-Theobald E, Louissaint J, Maraj B, et al. Systematic review: radiomics for the diagnosis and prognosis of hepatocellular carcinoma[J]. Aliment Pharmacol Ther, 2021, 54(7): 890-901.DOI: 10.1111/apt.16563.
|
| [18] |
Tang VH, Duong STM, Nguyen CDT, et al. Wavelet radiomics features from multiphase CT images for screening hepatocellular carcinoma: analysis and comparison[J]. Sci Rep, 2023, 13(1): 19559.DOI: 10.1038/s41598-023-46695-8.
|
| [19] |
Ma Y, Gong Y, Qiu Q, et al. Research on multi-model imaging machine learning for distinguishing early hepatocellular carcinoma[J]. BMC Cancer, 2024, 24(1): 363.DOI: 10.1186/s12885-024-12109-9.
|
| [20] |
Castaldo A, De Lucia DR, Pontillo G, et al. State of the art in artificial intelligence and radiomics in hepatocellular carcinoma[J]. Diagnostics, 2021, 11(7): 1194.DOI: 10.3390/diagnostics11071194.
|
| [21] |
Hamm CA, Wang CJ, Savic LJ, et al. Deep learning for liver tumor diagnosis part I: development of a convolutional neural network classifier for multi-phasic MRI[J]. Eur Radiol, 2019, 29(7): 3338-3347.DOI: 10.1007/s00330-019-06205-9.
|
| [22] |
|
| [23] |
Pang B, Zuo B, Huang L, et al. Real-world efficacy and safety of TACE-HAIC combined with TKIs and PD-1 inhibitors in initially unresectable hepatocellular carcinoma[J]. Int Immunopharmacol, 2024, 137: 112492.DOI: 10.1016/j.intimp.2024.112492.
|
| [24] |
Zhang M, Kuang B, Zhang J, et al. Enhancing prognostic prediction in hepatocellular carcinoma post-TACE: a machine learning approach integrating radiomics and clinical features[J]. Front Med, 2024, 11: 1419058.DOI: 10.3389/fmed.2024.1419058.
|
| [25] |
Deng K, Chen T, Leng Z, et al. Radiomics as a tool for prognostic prediction in transarterial chemoembolization for hepatocellular carcinoma: a systematic review and meta-analysis[J]. Radiol Med, 2024, 129(8): 1099-1117.DOI: 10.1007/s11547-024-01840-9.
|
| [26] |
Bai H, Meng S, Xiong C, et al. Preoperative CECT-based radiomic signature for predicting the response of transarterial chemoembolization (TACE) therapy in hepatocellular carcinoma[J]. Cardiovasc Intervent Radiol, 2022, 45(10): 1524-1533.DOI: 10.1007/s00270-022-03221-z.
|
| [27] |
Zhao Y, Wang N, Wu J, et al. Radiomics analysis based on contrast-enhanced MRI for prediction of therapeutic response to transarterial chemoembolization in hepatocellular carcinoma[J]. Front Oncol, 2021, 11: 582788.DOI: 10.3389/fonc.2021.582788.
|
| [28] |
Sun Z, Shi Z, Xin Y, et al. Contrast-enhanced CT imaging features combined with clinical factors to predict the efficacy and prognosis for transarterial chemoembolization of hepatocellular carcinoma[J]. Acad Radiol, 2023, 30: S81-S91.DOI: 10.1016/j.acra.2022.12.031.
|
| [29] |
Zhou M, Zhang P, Mao Q, et al. Multisequence MRI-based radiomic features combined with inflammatory indices for predicting the overall survival of HCC patients after TACE[J]. J Hepatocell Carcinoma, 2024, 11: 2049-2061.DOI: 10.2147/JHC.S481301.
|
| [30] |
Kuang F, Gao Y, Zhou Q, et al. MRI radiomics combined with clinicopathological factors for predicting 3-year overall survival of hepatocellular carcinoma after hepatectomy[J]. J Hepatocell Carcinoma, 2024, 11: 1445-1457.DOI: 10.2147/JHC.S464916.
|
| [31] |
Liu F, Liu D, Wang K, et al. Deep learning radiomics based on contrast-enhanced ultrasound might optimize curative treatments for very-early or early-stage hepatocellular carcinoma patients[J]. Liver Cancer, 2020, 9(4): 397-413.DOI: 10.1159/000505694.
|
| [32] |
Hagiwara S, Nishida N, Kudo M. Advances in immunotherapy for hepatocellular carcinoma[J]. Cancers, 2023, 15(7): 2070.DOI: 10.3390/cancers15072070.
|
| [33] |
Llovet JM, Kelley RK, Villanueva A, et al. Hepatocellular carcinoma[J]. Nat Rev Dis Primers, 2021, 7: 6.DOI: 10.1038/s41572-020-00240-3.
|
| [34] |
Chen Y, Yang C, Sheng L, et al. The era of immunotherapy in hepatocellular carcinoma: the new mission and challenges of magnetic resonance imaging[J]. Cancers, 2023, 15(19): 4677.DOI: 10.3390/cancers15194677.
|
| [35] |
Cui H, Zeng L, Li R, et al. Radiomics signature based on CECT for non-invasive prediction of response to anti-PD-1 therapy in patients with hepatocellular carcinoma[J]. Clin Radiol, 2023, 78(2): e37-e44.DOI: 10.1016/j.crad.2022.09.113.
|
| [36] |
Moriguchi M, Kataoka S, Itoh Y. Evolution of systemic treatment for hepatocellular carcinoma: changing treatment strategies and concepts[J]. Cancers, 2024, 16(13): 2387.DOI: 10.3390/cancers16132387.
|
| [37] |
Hua Y, Sun Z, Xiao Y, et al. Pretreatment CT-based machine learning radiomics model predicts response in unresectable hepatocellular carcinoma treated with lenvatinib plus PD-1 inhibitors and interventional therapy[J]. J Immunother Cancer, 2024, 12(7): e008953.DOI: 10.1136/jitc-2024-008953.
|
| [38] |
Li Y, Li X, Xiao X, et al. A novel hybrid model for predicting tertiary lymphoid structures and targeted immunotherapy outcomes in hepatocellular carcinoma: a multicenter retrospective study[J]. Eur Radiol, 2025, 35(6): 3206-3222.DOI: 10.1007/s00330-024-11255-9.
|
| [39] |
Erstad DJ, Tanabe KK. Prognostic and therapeutic implications of microvascular invasion in hepatocellular carcinoma[J]. Ann Surg Oncol, 2019, 26(5): 1474-1493.DOI: 10.1245/s10434-019-07227-9.
|
| [40] |
Lei Y, Feng B, Wan M, et al. Predicting microvascular invasion in hepatocellular carcinoma with a CT-and MRI-based multimodal deep learning model[J]. Abdom Radiol, 2024, 49(5): 1397-1410.DOI: 10.1007/s00261-024-04202-1.
|
| [41] |
Fu S, Pan M, Zhang J, et al. Deep learning-based prediction of future extrahepatic metastasis and macrovascular invasion in hepatocellular carcinoma[J]. J Hepatocell Carcinoma, 2021, 8: 1065-1076.DOI: 10.2147/JHC.S319639.
|
| [42] |
Chan LWC, Wong SCC, Cho WCS, et al. Primary tumor radiomic model for identifying extrahepatic metastasis of hepatocellular carcinoma based on contrast enhanced computed tomography[J]. Diagnostics, 2022, 13(1): 102.DOI: 10.3390/diagnostics13010102.
|
| [43] |
Zhao JW, Shu X, Chen XX, et al. Prediction of early recurrence of hepatocellular carcinoma after liver transplantation based on computed tomography radiomics nomogram[J]. Hepatobiliary Pancreat Dis Int, 2022, 21(6): 543-550.DOI: 10.1016/j.hbpd.2022.05.013.
|
| [44] |
Zhou G, Zhou Y, Xu X, et al. MRI-based radiomics signature: a potential imaging biomarker for prediction of microvascular invasion in combined hepatocellular-cholangiocarcinoma[J]. Abdom Radiol, 2024, 49(1): 49-59.DOI: 10.1007/s00261-023-04049-y.
|
| [45] |
Ren L, Chen DB, Yan X, et al. Bridging the gap between imaging and molecular characterization: current understanding of radiomics and radiogenomics in hepatocellular carcinoma[J]. J Hepatocell Carcinoma, 2024, 11: 2359-2372.DOI: 10.2147/JHC.S423549.
|
| [46] |
Liao H, Jiang H, Chen Y, et al. Predicting genomic alterations of phosphatidylinositol-3 kinase signaling in hepatocellular carcinoma: a radiogenomics study based on next-generation sequencing and contrast-enhanced CT[J]. Ann Surg Oncol, 2022.DOI: 10.1245/s10434-022-11505-4.
|
| [47] |
Wen H, Liang R, Liu X, et al. Predicting pathological response of neoadjuvant conversion therapy for hepatocellular carcinoma patients using CT-based radiomics model[J]. J Hepatocell Carcinoma, 2024, 11: 2145-2157.DOI: 10.2147/JHC.S487370.
|
| [48] |
Li S, Dai Y, Chen J, et al. MRI-based habitat imaging in cancer treatment: current technology, applications, and challenges[J]. Cancer Imaging, 2024, 24(1): 107.DOI: 10.1186/s40644-024-00758-9.
|
| [49] |
Zhang M, Li Z, Yin Y. Analysis of treatment response based on 1. 5T magnetic resonance imaging texture analysis in stereotactic body radiotherapy of hepatocellular carcinoma[J]. J Radiat Res Appl Sci, 2024, 17(1): 100759.DOI: 10.1016/j.jrras.2023.100759.
|
| [50] |
Gu J, Bao S, Akemuhan R, et al. Radiomics based on contrast-enhanced CT for recognizing c-met-positive hepatocellular carcinoma: a noninvasive approach to predict the outcome of sorafenib resistance[J]. Mol Imaging Biol, 2023, 25(6): 1073-1083.DOI: 10.1007/s11307-023-01870-1.
|
| [51] |
Wu J, Mayer AT, Li R. Integrated imaging and molecular analysis to decipher tumor microenvironment in the era of immunotherapy[J]. Semin Cancer Biol, 2022, 84: 310-328.DOI: 10.1016/j.semcancer.2020.12.005.
|
| [52] |
Wang W, Gu D, Wei J, et al. A radiomics-based biomarker for cytokeratin 19 status of hepatocellular carcinoma with gadoxetic acid-enhanced MRI[J]. Eur Radiol, 2020, 30(5): 3004-3014.DOI: 10.1007/s00330-019-06585-y.
|
| [53] |
Wu HY, Cao SY, Xu ZG, et al. Construction of a radiogenomic signature based on endoplasmic reticulum stress for predicting prognosis and systemic combination therapy response in hepatocellular carcinoma[J]. BMC Cancer, 2025, 25(1): 131.DOI: 10.1186/s12885-025-13433-4.
|
| [54] |
Gu Y, Huang H, Tong Q, et al. Multi-view radiomics feature fusion reveals distinct immuno-oncological characteristics and clinical prognoses in hepatocellular carcinoma[J]. Cancers, 2023, 15(8): 2338.DOI: 10.3390/cancers15082338.
|
| [55] |
Mostafa G, Mahmoud H, Abd El-Hafeez T, et al. The power of deep learning in simplifying feature selection for hepatocellular carcinoma: a review[J]. BMC Med Inform Decis Mak, 2024, 24(1): 287.DOI: 10.1186/s12911-024-02682-1.
|
| [56] |
Wang Y, Zhang Y, Xiao J, et al. Multicenter integration of MR radiomics, deep learning, and clinical indicators for predicting hepatocellular carcinoma recurrence after thermal ablation[J]. J Hepatocell Carcinoma, 2024, 11: 1861-1874.DOI: 10.2147/JHC.S482760.
|
| [57] |
Zhao Y, Wang S, Wang Y, et al. Deep learning radiomics based on contrast enhanced MRI for preoperatively predicting early recurrence in hepatocellular carcinoma after curative resection[J]. Front Oncol, 2024, 14: 1446386.DOI: 10.3389/fonc.2024.1446386.
|
| [58] |
Miao J, Xu S, Zou B, et al. ResNet based on feature-inspired gating strategy[J]. Multimed Tools Appl, 2022, 81(14): 19283-19300.DOI: 10.1007/s11042-021-10802-6.
|
| [59] |
Xie XY, Chen R. Research progress of MRI-based radiomics in hepatocellular carcinoma[J]. Front Oncol, 2025, 15: 1420599.DOI: 10.3389/fonc.2025.1420599.
|
| [60] |
Floca R, Bohn J, Haux C, et al. Radiomics workflow definition & challenges-German priority program 2177 consensus statement on clinically applied radiomics[J]. Insights Imaging, 2024, 15(1): 124.DOI: 10.1186/s13244-024-01704-w.
|
| [61] |
|
| [62] |
Xia T, Zhao B, Li B, et al. MRI-based radiomics and deep learning in biological characteristics and prognosis of hepatocellular carcinoma: opportunities and challenges[J]. J Magn Reson Imaging, 2024, 59(3): 767-783.DOI: 10.1002/jmri.28982.
|
| [63] |
Huang W, Pan Y, Wang H, et al. Delta-radiomics analysis based on multi-phase contrast-enhanced MRI to predict early recurrence in hepatocellular carcinoma after percutaneous thermal ablation[J]. Acad Radiol, 2024, 31(12): 4934-4945.DOI: 10.1016/j.acra.2024.06.002.
|
| [64] |
Ho LM, Lam SK, Zhang J, et al. Association of multi-phasic MR-based radiomic and dosimetric features with treatment response in unresectable hepatocellular carcinoma patients following novel sequential TACE-SBRT-immunotherapy[J]. Cancers, 2023, 15(4): 1105.DOI: 10.3390/cancers15041105.
|
| [65] |
Bakas S, Vollmuth P, Galldiks N, et al. Artificial Intelligence for Response Assessment in Neuro Oncology (AI-RANO), part 2: recommendations for standardisation, validation, and good clinical practice[J]. Lancet Oncol, 2024, 25(11): e589-e601.DOI: 10.1016/S1470-2045(24)00315-2.
|