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中华肝脏外科手术学电子杂志 ›› 2017, Vol. 06 ›› Issue (04) : 289 -292. doi: 10.3877/cma.j.issn.2095-3232.2017.04.012

所属专题: 文献

临床研究

肝细胞癌肝切除术后出血的防治
李清汉1, 甄作均1,(), 陈应军1, 何尹韬1   
  1. 1. 528000 广东省佛山市第一人民医院肝脏胰腺外科
  • 收稿日期:2017-03-17 出版日期:2017-08-10
  • 通信作者: 甄作均
  • 基金资助:
    佛山市医学类科技攻关项目(2014AB00301)

Prevention and treatment of hemorrhage after hepatectomy for hepatocellular carcinoma

Qinghan Li1, Zuojun Zhen1,(), Yingjun Chen1, Yintao He1   

  1. 1. Department of Hepatobiliary Surgery, the First People's Hospital of Foshan, Foshan 528000, China
  • Received:2017-03-17 Published:2017-08-10
  • Corresponding author: Zuojun Zhen
  • About author:
    Corresponding author:Zhen Zuojun, Email:
引用本文:

李清汉, 甄作均, 陈应军, 何尹韬. 肝细胞癌肝切除术后出血的防治[J/OL]. 中华肝脏外科手术学电子杂志, 2017, 06(04): 289-292.

Qinghan Li, Zuojun Zhen, Yingjun Chen, Yintao He. Prevention and treatment of hemorrhage after hepatectomy for hepatocellular carcinoma[J/OL]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2017, 06(04): 289-292.

目的

探讨肝细胞癌(肝癌)患者肝切除术后出血的防治方法。

方法

回顾性分析2010年12月至2016年12月在佛山市第一人民医院接受肝切除术且术后出血的10例肝癌患者临床资料。其中男8例,女2例;年龄42~68岁,中位年龄48岁。接受腹腔镜肝中叶部分肝段切除术5例,开腹右半肝切除术2例,腹腔镜肝Ⅴ、Ⅷ段及部分Ⅳ段切除术1例,腹腔镜左半肝切除术2例。患者均签署知情同意书,符合医学伦理学规定。分析术后出血的原因及其治疗方法。

结果

术后48 h内出血9例。其中5例为肝创面出血,1例肝短静脉出血,1例肝右静脉出血,1例肝静脉出血,1例胆囊动脉出血,患者均经手术探查后找到出血点,予以确切缝扎止血。1例术后10余天突发出血,该患者为胃右动脉根部出血,无法行栓塞止血,经手术探查,修补肝总动脉出血点及肝创面胆漏处。所有患者随访两个月无再次出血或其他并发症发生。

结论

肝癌肝切除术后出血重在预防,术前行严格评估、术中精细且规范操作、术后严密观察和及时的外科干预可降低术后死亡率。

Objective

To investigate the prevention and treatment of hemorrhage after hepatectomy for patients with hepatocellular carcinoma (HCC).

Methods

Clinical data of 10 HCC patients with hemorrhage after hepatectomy in the First People's Hospital of Foshan between December 2010 and December 2016 were retrospectively analyzed. Among them, 8 cases were males and 2 were females, aged 42-68 years old with a median age of 48 years old. Laparoscopic resection of patial segment of the middle lobe was performed on 5 cases, open right hemihepatectomy on 2, laparoscopic resection of segments Ⅴ, Ⅷ and patial segments Ⅳ on 1, and laparoscopic left hemihepatectomy on 2. The informed consents of all patients were obtained and the local ethical committee approval was received. The causes and treatment of postoperative hemorrhage were analyzed.

Results

Hemorrhage within postoperative 48 h was observed in 9 cases, including 5 cases with the liver wound surface hemorrhage, 1 with short hepatic vein hemorrhage, 1 with right hepatic vein hemorrhage, 1 with hepatic vein hemorrhage and 1 with gallbladder artery hemorrhage. The hemorrhagic spots were all found after exploratory surgery and were definitely sutured for hemostasis. One case suddenly suffered from hemorrhage over 10 d after surgery. The patients could not undergo embolization due to hemorrhage at the root of right gastric artery, thus surgical exploration was performed and the hemorrhagic spots at the common hepatic artery and bile leakage on the liver wound surface were repaired. No rebleeding or other complications were observed during 2 months follow-up.

Conclusions

Prevention is the emphasis for hemorrhage after hepatectomy for HCC. Strict preoperative evaluation, precise and standard intraoperative operation, intimate postoperative observation and timely surgical intervention can decrease postoperative mortality.

[1]
Dell AJ, Krige JE, Jonas E, et al. Incidence and management of postoperative bile leaks: a prospective cohort analysis of 467 liver resections[J]. S Afr J Surg, 2016, 54(3):18-22.
[2]
Yang T, Zhang J, Lu JH, et al. Risk factors influencing postoperative outcomes of major hepatic resection of hepatocellular carcinoma for patients with underlying liver diseases[J]. World J Surg, 2011, 35(9):2073-2082.
[3]
Coe TM, Fong ZV, Wilson SE, et al. Outcomes improvement is not continuous along the learning curve for pancreaticoduodenectomy at the hospital level[J]. J Gastrointest Surg, 2015, 19(12):2132-2137.
[4]
Asiyanbola B, Chang D, Gleisner AL, et al. Operative mortality after hepatic resection: are literature-based rates broadly applicable?[J]. J Gastrointest Surg, 2008, 12(5):842-851.
[5]
Zhao YN, Zhang YQ, Ye JZ, et al. Hepatic resection versus transarterial chemoembolization for patients with Barcelona Clinic Liver Cancer intermediate stage Child-Pugh A hepatocellular carcinoma[J]. Exp Ther Med, 2016, 12(6):3813-3819.
[6]
Fan ST. Liver functional reserve estimation: state of the art and relevance for local treatments: the Eastern perspective[J]. J Hepatobiliary Pancreat Sci, 2010, 17(4):380-384.
[7]
汤地,李勋,姜春林,等.术前ICGR15联合标准残肝体积对巨大肝细胞癌精准肝切除术后肝功能不全的预测价值[J/CD].中华肝脏外科手术学电子杂志,2015,4(4):222-226.
[8]
万春,戴兵,万品文.功能性残肝体积比联合ICGR15对选择性出入肝血流阻断肝切除术肝储备功能评估分析[J].腹部外科,2016,29(3):214-217.
[9]
吴志强,王卫东,林杰,等.吲哚菁绿清除试验在肝癌术前评估肝脏储备功能的临床应用[J].岭南现代临床外科,2015,15(4):389-393.
[10]
Pinato DJ, Sharma R, Allara E, et al. The ALBI grade provides objective hepatic reserve estimation across each BCLC stage of hepatocellular carcinoma[J]. J Hepatol, 2017, 66(2):338-346.
[11]
Wang Y, Zhang Y, Peitgen HO, et al. Precise local resection for hepatocellular carcinoma based on tumor-surrounding vascular anatomy revealed by 3D analysis[J]. Dig Surg, 2012, 29(2):99-106.
[12]
祝文,方驰华,范应方,等.原发性肝癌三维可视化诊治平台的构建及临床应用[J/CD].中华肝脏外科手术学电子杂志,2015,4(5):268-273.
[13]
蔡伟,向飞,黄耀欢,等.三维可视化技术在巨块型肝癌可切除性评估及手术规划中的应用价值[J].中华消化外科杂志,2017,16(1):53-58.
[14]
Tian F, Wu JX, Rong WQ, et al. Three-dimensional morphometric analysis for hepatectomy of centrally located hepatocellular carcinoma: a pilot study[J]. World J Gastroenterol, 2015, 21(15):4607-4619.
[15]
Ryckx A, Christiaens C, Clarysse M, et al. Central venous pressure drop after hypovolemic phlebotomy is a strong independent predictor of ntraoperative blood loss during liver resection[J]. Ann Surg Oncol, 2017, 24(5):1367-1375.
[16]
Rekman J, Wherrett C, Bennett S, et al. Safety and feasibility of phlebotomy with controlled hypovolemia to minimize blood loss in liver resections[J]. Surgery, 2017, 161(3):650-657.
[17]
张日新,朱岭,汪娟,等.控制性低中心静脉压在肝切除术中的应用[J].中华实验外科杂志,2016,33(10):2324-2326.
[18]
Yang T, Li L, Zhong Q, et al. Risk factors of hospital mortality after re-laparotomy for post-hepatectomy hemorrhage[J]. World J Surg, 2013, 37(10):2394-2401.
[19]
Lim C, Dokmak S, Farges O, et al. Reoperation for post-hepatectomy hemorrhage: increased risk of mortality[J]. Langenbecks Arch Surg, 2014, 399(6):735-740.
[20]
Du ZG, Wei YG, Chen KF, et al. An accurate predictor of liver failure and death after hepatectomy: a single institution's experience with 478 consecutive cases[J]. World J Gastroenterol, 2014, 20(1):274-281.
[21]
Rahbari NN, Garden OJ, Padbury R, et al. Post-hepatectomy haemorrhage: a definition and grading by the International Study Group of Liver Surgery (ISGLS)[J]. HPB, 2011, 13(8):528-535.
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