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中华肝脏外科手术学电子杂志 ›› 2019, Vol. 08 ›› Issue (01) : 76 -80. doi: 10.3877/cma.j.issn.2095-3232.2019.01.018

所属专题: 文献

基础研究

基于Oncomine数据库分析STC 2在肝细胞癌中的表达及意义
刘荣强1, 林国桢1, 代天星1, 汪国营1,()   
  1. 1. 510630 广州,中山大学附属第三医院肝脏外科 肝脏移植中心
  • 收稿日期:2018-09-18 出版日期:2019-02-10
  • 通信作者: 汪国营
  • 基金资助:
    国家十三五科技重大专项(2017ZX10203205-006-001); 广东省科技计划项目(2014B020228003,2014A020211015); 广东省自然科学基金(2015A030312013,2015A030313038); 广州市科技计划项目(201400000001-3,158100076,2014J4100183)

Expression of STC 2 in hepatocellular carcinoma and its significance analysis based on Oncomine database

Rongqiang Liu1, Guozhen Lin1, Tianxing Dai1, Guoying Wang1,()   

  1. 1. Department of Liver Surgery, Liver Transplantation Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China
  • Received:2018-09-18 Published:2019-02-10
  • Corresponding author: Guoying Wang
  • About author:
    Corresponding author: Wang Guoying, Email:
引用本文:

刘荣强, 林国桢, 代天星, 汪国营. 基于Oncomine数据库分析STC 2在肝细胞癌中的表达及意义[J]. 中华肝脏外科手术学电子杂志, 2019, 08(01): 76-80.

Rongqiang Liu, Guozhen Lin, Tianxing Dai, Guoying Wang. Expression of STC 2 in hepatocellular carcinoma and its significance analysis based on Oncomine database[J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2019, 08(01): 76-80.

目的

探讨斯钙素2(STC 2)在肝细胞癌(肝癌)中的表达及临床意义。

方法

收集Oncomine数据库中有关STC 2的相关信息,对资料进行二次分析,并研究STC 2在肝癌中的作用。肝癌组织与癌旁组织间STC 2表达比较采用t检验。STC 2表达与肝癌患者生存预后关系分析采用Kaplan-Meier生存曲线及Log-rank检验。

结果

Oncomine数据库总共收集415项不同类型的研究,STC 2表达增高24项,表达降低5项。其中有8项研究涉及STC 2在肝癌组织与癌旁组织中的表达,与癌旁组织相比,STC 2在肝癌组织中高表达(P<0.05)。两项研究发现STC 2与肝癌患者总体生存无相关性(χ2=3.233,1.787;P>0.05),且与患者肿瘤复发率也不存在相关性(χ2=3.195,1.514;P>0.05)。

结论

基于Oncomine数据库分析发现STC 2在肝癌组织高表达,但其与肝癌预后无明确相关性。

Objective

To investigate the expression and clinical significance of stanniocalcin 2 (STC 2) in hepatocellular carcinoma (HCC).

Methods

Information about STC 2 was collected from the Oncomine database and was secondarily analyzed to investigate the role of STC 2 in HCC. The expression levels of STC 2 in HCC and adjacent tissues were compared by t test. The relationship between STC 2 expression and survival prognosis in HCC patients was analyzed by Kaplan-Meier survival curve and Log-rank test.

Results

A total of 415 different types of studies were selected from the Oncomine database. The expression level of STC 2 was up-regulated in 24 studies and down-regulated in 5. The expression of STC 2 in HCC and the adjacent tissues was analyzed in 8 studies. STC 2 highly expressed in HCC tissues compared with that in the adjacent tissues (P<0.05). Two studies have demonstrated no correlation between STC 2 expression and the overall survival of HCC patients (χ2=3.233, 1.787; P>0.05), and no correlation was observed between STC 2 expression and the recurrence rate (χ2=3.195, 1.514; P>0.05).

Conclusions

The Oncomine database reveals that STC 2 is highly expressed in HCC tissues, but STC 2 expression is not significantly correlated with clinical prognosis of HCC patients.

图1 Oncomine数据库中STC2在不同类型肿瘤研究中的表达情况
图2 Oncomine数据库中STC 2在肝癌中的表达情况
图3 STC 2在不同肝癌研究芯片中的表达情况
图4 STC 2表达与肝癌预后的关系
[1]
Yokobori T, Mimori K, Ishii H, et al. Clinical significance of stanniocalcin 2 as a prognostic marker in gastric cancer[J]. Ann Surg Oncol, 2010, 17(10):2601-2607.
[2]
Lin S, Guo Q, Wen J, et al. Survival analyses correlate stanniocalcin 2overexpression to poor prognosis of nasopharyngeal carcinomas[J]. J Exp Clin Cancer Res, 2014, 33:26.
[3]
Meyer HA, Tölle A, Jung M, et al. Identification of stanniocalcin 2as prognostic marker in renal cell carcinoma[J]. Eur Urol, 2009, 55(3):669-678.
[4]
Wang YY, Li L, Zhao ZS, et al. Clinical utility of measuring expression levels of KAP1, TIMP1 and STC 2 in peripheral blood of patients with gastric cancer[J]. World J Surg Oncol, 2013, 11:81.
[5]
Zhou H, Li YY, Zhang WQ, et al. Expression of stanniocalcin-1 and stanniocalcin-2 in laryngeal squamous cell carcinoma and correlations with clinical and pathological parameters[J]. PloS One, 2014, 9(4):e95466.
[6]
Kita Y, Mimori K, Iwatsuki M, et al. STC 2: a predictive marker for lymph node metastasis in esophageal squamous-cell carcinoma[J]. Ann Surg Oncol, 2011, 18(1):261-272.
[7]
Chen X, Cheung ST, So S, et al. Gene expression patterns in human liver cancers [J]. Mol Biol Cell, 2002, 13(6):1929-1939.
[8]
Roessler S, Jia HL, Budhu A, et al. A unique metastasis gene signature enables prediction of tumor relapse in early-stage hepatocellular carcinoma patients[J]. Cancer Res, 2010, 70(24): 10202-10212.
[9]
Wurmbach E, Chen YB, Khitrov G, et al. Genome-wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma[J]. Hepatology, 2007, 45(4):938-947.
[10]
Guichard C, Amaddeo G, Imbeaud S, et al. Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma[J]. Nat Genet, 2012, 44(6):694-698.
[11]
Mas VR, Maluf DG, Archer KJ, et al. Genes involved in viral carcinogenesis and tumor initiation in hepatitis C virus-induced hepatocellular carcinoma[J]. Mol Med, 2009, 15(3/4):85-94.
[12]
Jemal A, Bray F, Center MM, et al. Global cancer statistics[J]. CA Cancer J Clin, 2011, 61(2):69-90.
[13]
Umemura T, Kiyosawa K. Epidemiology of hepatocellular carcinoma in Japan[J]. Hepatol Res, 2007, 37 Suppl 2:S95-100.
[14]
Zhu W, Peng Y, Wang L, et al. Identification of α-fetoprotein-specific T-cell receptors for hepatocellular carcinoma immunotherapy[J]. Hepatology, 2018, DOI:10.1002/hep.29844[Epub ahead of print].
[15]
Shen XJ, Gu K, Shi JP, et al. Increased expression of stanniocalcin 2 is associated with tumor progression after radiotherapy in patients with cervical carcinoma[J]. Int J Clin Exp Pathol, 2014, 7(12):8770-8776.
[16]
Na SS, Aldonza MB, Sung HJ, et al. Stanniocalcin-2 (STC2): a potential lung cancer biomarker promotes lung cancer metastasis and progression[J]. Biochim Biophys Acta, 2015, 1854(6):668-676.
[17]
Law AY, Wong CK. Stanniocalcin-2 is a HIF-1 target gene that promotes cell proliferation in hypoxia[J]. Exp Cell Res, 2010, 316(3):466-476.
[18]
Law AY, Wong CK. Stanniocalcin-1 and-2 promote angiogenic sprouting in HUVECs via VEGF/VEGFR 2 and angiopoietin signaling pathways[J]. Mol Cell Endocrinol, 2013, 374(1/2):73-81.
[19]
Chen B, Zeng X, He Y, et al. STC 2 promotes the epithelial-mesenchymal transition of colorectal cancer cells through AKT-ERK signaling pathways[J]. Oncotarget, 2016, 7(44):71400-71416.
[20]
Zhang ZH, Wu YG, Qin CK, et al. Stanniocalcin 2 expression predicts poor prognosis of hepatocellular carcinoma[J]. Oncol Lett, 2014, 8(5):2160-2164.
[21]
Wang H, Wu K, Sun Y, et al. STC 2 is upregulated in hepatocellular carcinoma and promotes cell proliferation and migration in vitro[J]. BMB Rep, 2012, 45(11):629-634.
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