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中华肝脏外科手术学电子杂志 ›› 2023, Vol. 12 ›› Issue (02) : 243 -246. doi: 10.3877/cma.j.issn.2095-3232.2023.02.023

所属专题: 临床研究

综述

肝细胞癌NK细胞及其相关免疫治疗研究进展
谭天华1, 宋京海2,()   
  1. 1. 100730 中国医学科学院北京协和医学院研究生院;100730 北京医院国家老年医学中心 中国医学科学院老年医学研究院普通外科(肝胆胰外科)
    2. 100730 北京医院国家老年医学中心 中国医学科学院老年医学研究院普通外科(肝胆胰外科)
  • 收稿日期:2022-12-26 出版日期:2023-03-28
  • 通信作者: 宋京海
  • 基金资助:
    国家自然科学基金(81671581)

Research progress of natural killer cell and related immunotherapy for hepatocellular carcinoma

Tianhua Tan1, Jinghai Song2()   

  • Received:2022-12-26 Published:2023-03-28
  • Corresponding author: Jinghai Song
引用本文:

谭天华, 宋京海. 肝细胞癌NK细胞及其相关免疫治疗研究进展[J/OL]. 中华肝脏外科手术学电子杂志, 2023, 12(02): 243-246.

Tianhua Tan, Jinghai Song. Research progress of natural killer cell and related immunotherapy for hepatocellular carcinoma[J/OL]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2023, 12(02): 243-246.

原发性肝癌是常见的恶性肿瘤之一,目前是我国第5位常见恶性肿瘤及第2位肿瘤致死病因,其中肝细胞癌(HCC)占75%~85%[1]。早期HCC通过手术切除、肝移植、局部消融等方式可取得根治性治疗效果,但术后仍存在较高的复发率,部分HCC患者在首次就医时已失去手术机会,因此,为晚期和复发患者寻找改善预后的治疗手段尤为重要。NK细胞是固有免疫系统的重要组成部分,在肿瘤免疫中起到免疫监视和免疫杀伤的作用。HCC患者外周血和肝脏中,NK细胞均表现出数量减少、功能衰竭的特点,失去了原有的抗肿瘤功能[2]。明确肿瘤微环境(tumor microenvironment,TME)中对NK细胞产生影响的各种成分及机制,对HCC免疫治疗的研究方向具有一定的指导意义。本文拟对HCC微环境中NK细胞及其相关免疫治疗予以综述。

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