切换至 "中华医学电子期刊资源库"

中华肝脏外科手术学电子杂志 ›› 2017, Vol. 06 ›› Issue (05) : 347 -350. doi: 10.3877/cma.j.issn.2095-3232.2017.05.003

所属专题: 文献

专题笔谈

肝细胞癌的免疫治疗现状与展望
李汛1,(), 刘小军2, 严俊1   
  1. 1. 730000 兰州大学第一医院普外二科 甘肃省肝胆胰外科研究所 兰州大学临床医学院肿瘤防治中心 甘肃省生物治疗与再生医学重点实验室
    2. 730000 兰州大学第一医院肿瘤内科
  • 收稿日期:2017-07-03 出版日期:2017-10-10
  • 通信作者: 李汛
  • 基金资助:
    国家自然科学基金面上项目(31270543); 甘肃省科技重大项目(甘财教[2013]131号); 中央高校基本科研业务费专项资金重大需求培育项目(lzujbky-2013-m04)

Current situation and prospect of immunotherapy for hepatocellular carcinoma

Xun Li1(), Xiaojun Liu2, Jun Yan1   

  • Received:2017-07-03 Published:2017-10-10
  • Corresponding author: Xun Li
引用本文:

李汛, 刘小军, 严俊. 肝细胞癌的免疫治疗现状与展望[J/OL]. 中华肝脏外科手术学电子杂志, 2017, 06(05): 347-350.

Xun Li, Xiaojun Liu, Jun Yan. Current situation and prospect of immunotherapy for hepatocellular carcinoma[J/OL]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2017, 06(05): 347-350.

[1]
吕毅,张谞丰.肝细胞肝癌的多学科协作组概念及其实践[J/CD].中华肝脏外科手术学电子杂志,2013,2(1):1-3.
[2]
Yeung OW, Lo CM, Ling CC, et al. Alternatively activated (M2) macrophages promote tumour growth and invasiveness in hepatocellular carcinoma[J]. J Hepatol, 2015, 62(3):607-616.
[3]
Zhao HQ, Li WM, Lu ZQ, et al. Roles of Tregs in development of hepatocellular carcinoma: a meta-analysis[J]. World J Gastroenterol, 2014, 20(24):7971-7978.
[4]
McDermott DF, Atkins MB. PD-1 as a potential target in cancer therapy[J]. Cancer Med, 2013, 2(5):662-673.
[5]
Carulli L, Anzivino C. Telomere and telomerase in chronic liver disease and hepatocarcinoma[J]. World J Gastroenterol, 2014, 20(20):6287-6292.
[6]
Mizukoshi E, Nakagawa H, Kitahara M, et al. Immunological features of T cells induced by human telomerase reverse transcriptase-derived peptides in patients with hepatocellular carcinoma[J]. Cancer lett, 2015, 364(2):98-105.
[7]
Schumacher TN, Schreiber RD. Neoantigens in cancer immunotherapy[J]. Science, 2015, 348(6230):69-74.
[8]
Zhong JH, Ma L, Wu LC, et al. Adoptive immunotherapy for postoperative hepatocellular carcinoma: a systematic review[J]. Int J Clin Pract, 2012, 66(1):21-27.
[9]
Pan K, Li YQ, Wang W, et al. The efficacy of cytokine-induced killer cell infusion as an adjuvant therapy for postoperative hepatocellular carcinoma patients[J]. Ann Surg Oncol, 2013, 20(13):4305-4311.
[10]
Li X, Dai D, Song X, et al. A meta-analysis of cytokine-induced killer cells therapy in combination with minimally invasive treatment for hepatocellular carcinoma[J]. Clin Res Hepatol Gastroenterol, 2014, 38(5):583-591.
[11]
Lee JH, Lee JH, Lim YS, et al. Adjuvant immunotherapy with autologous cytokine-induced killer cells for hepatocellular carcinoma[J]. Gastroenterology, 2015, 148(7):1383-1391.
[12]
Erös de Bethlenfalva-Hora C, Mertens JC, Piguet AC, et al. Radiofrequency ablation suppresses distant tumour growth in a novel rat model of multifocal hepatocellular carcinoma[J]. Clin Sci, 2014, 126(3):243-252.
[13]
Gehring AJ, Xue SA, Ho ZZ, et al. Engineering virus-specific T cells that target HBV infected hepatocytes and hepatocellular carcinoma cell lines[J]. J Hepatol, 2011, 55(1):103-110.
[14]
Gao H, Li K, Tu H, et al. Development of T cells redirected to glypican-3 for the treatment of hepatocellular carcinoma[J]. Clin Cancer Res, 2014, 20(24):6418-6428.
[15]
Cany J, Tran L, Gauttier V, et al. Immunotherapy of hepatocellular carcinoma: is there a place for regulatory T-lymphocyte depletion?[J]. Immunotherapy, 2011, 3(4 Suppl):32-34.
[16]
Lee D, Chung YH, Kim JA, et al. Safety and efficacy of adjuvant pegylated interferon therapy for metastatic tumor antigen 1-positive hepatocellular carcinoma[J]. Cancer, 2013, 119(12):2239-2246.
[17]
Wang L, Jia D, Duan F, et al. Combined anti-tumor effects of IFN-α and sorafenib on hepatocellular carcinoma in vitro and in vivo[J]. Biochem Biophys Res Commun, 2012, 422(4):687-692.
[18]
Duffy A, Kerkar SP, Kleiner DE, et al. Paired tumor biopsy analysis and safety data from a pilot study evaluating Tremelimumab-a monoclonal antibody against CTLA-4 in combination with ablative therapy in patients with hepatocellular carcinoma (HCC)[J]. J Immunother Cancer, 2014, 2 Suppl 3:P98.
[19]
El Ansary M, Mogawer S, Elhamid SA, et al. Immunotherapy by autologous dendritic cell vaccine in patients with advanced HCC[J]. J Cancer Res Clin Oncol, 2013, 139(1):39-48.
[20]
Lee WC, Wang HC, Hung CF, et al. Vaccination of advanced hepatocellular carcinoma patients with tumor lysate-pulsed dendritic cells: a clinical trial[J]. J Immunother, 2005, 28(5):496-504.
[21]
Tada F, Abe M, Hirooka M, et al. Phase I/II study of immunotherapy using tumor antigen-pulsed dendritic cells in patients with hepatocellular carcinoma[J]. Int J Oncol, 2012, 41(5):1601-1609.
[1] 中国医师协会肝癌专业委员会. 肝细胞癌伴微血管侵犯诊断和治疗中国专家共识(2024版)[J/OL]. 中华普通外科学文献(电子版), 2024, 18(05): 313-324.
[2] 李华志, 曹广, 刘殿刚, 张雅静. 不同入路下行肝切除术治疗原发性肝细胞癌的临床对比[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 52-55.
[3] 常小伟, 蔡瑜, 赵志勇, 张伟. 高强度聚焦超声消融术联合肝动脉化疗栓塞术治疗原发性肝细胞癌的效果及安全性分析[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 56-59.
[4] 屈翔宇, 张懿刚, 李浩令, 邱天, 谈燚. USP24及其共表达肿瘤代谢基因在肝细胞癌中的诊断和预后预测作用[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 659-662.
[5] 谢汶歆, 马乐, 刘晔, 曹晓明, 张万春. 前列腺特异性膜抗原PET/CT在肾癌诊疗中的应用价值[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(05): 514-519.
[6] 王岩, 钱宏阳, 朱寅杰, 董柏君, 潘家骅, 薛蔚. 机器人辅助单孔腹膜外根治性前列腺切除治疗高危前列腺癌的瘤控效果初探[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(05): 435-440.
[7] 陈伟杰, 何小东. 胆囊癌免疫靶向治疗进展[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 763-768.
[8] 公宇, 廖媛, 尚梅. 肝细胞癌TACE术后复发影响因素及预测模型建立[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 818-824.
[9] 李一帆, 朱帝文, 任伟新, 鲍应军, 顾俊鹏, 张海潇, 曹耿飞, 阿斯哈尔·哈斯木, 纪卫政. 血GP73水平在原发性肝癌TACE疗效评价中的作用[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 825-830.
[10] 刘敏思, 李荣, 李媚. 基于GGT与Plt比值的模型在HBV相关肝细胞癌诊断中的作用[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 831-835.
[11] 焦振东, 惠鹏, 金上博. 三维可视化结合ICG显像技术在腹腔镜肝切除术治疗复发性肝癌中的应用[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 859-864.
[12] 陈晓鹏, 王佳妮, 练庆海, 杨九妹. 肝细胞癌VOPP1表达及其与预后的关系[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 876-882.
[13] 袁雨涵, 杨盛力. 体液和组织蛋白质组学分析在肝癌早期分子诊断中的研究进展[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 883-888.
[14] 吴警, 吐尔洪江·吐逊, 温浩. 肝切除术前肝功能评估新进展[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 889-893.
[15] 陈倩倩, 袁晨, 刘基, 尹婷婷. 多层螺旋CT 参数、癌胚抗原、错配修复基因及病理指标对结直肠癌预后的影响[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(06): 507-511.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?