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中华肝脏外科手术学电子杂志 ›› 2022, Vol. 11 ›› Issue (06) : 559 -562. doi: 10.3877/cma.j.issn.2095-3232.2022.06.006

所属专题: 综述

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靶向和免疫治疗在肝细胞癌新辅助治疗中的应用
傅仰楷1, 严茂林1,()   
  1. 1. 350000 福州,福建省立医院肝胆胰外科
  • 收稿日期:2022-08-15 出版日期:2022-12-10
  • 通信作者: 严茂林
  • 基金资助:
    福建省自然科学基金(2020J011105)

Application of targeted therapy and immunotherapy in neoadjuvant therapy of hepatocellular carcinoma

Yangkai Fu1, Maolin Yan1()   

  • Received:2022-08-15 Published:2022-12-10
  • Corresponding author: Maolin Yan
引用本文:

傅仰楷, 严茂林. 靶向和免疫治疗在肝细胞癌新辅助治疗中的应用[J/OL]. 中华肝脏外科手术学电子杂志, 2022, 11(06): 559-562.

Yangkai Fu, Maolin Yan. Application of targeted therapy and immunotherapy in neoadjuvant therapy of hepatocellular carcinoma[J/OL]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2022, 11(06): 559-562.

我国是肝细胞癌(HCC)大国,全世界约半数新发HCC患者来自中国,每年死亡病例数占全球55%以上[1,2]。HCC作为我国第4位常见的恶性肿瘤,其病死率占癌症相关死亡原因的第2位[3]。目前HCC的治疗方式包括根治性治疗(手术切除、肝移植、射频消融、微波消融)、系统治疗(靶向治疗、免疫治疗)、支持治疗等。BCLC分期0~A期患者可选择肝切除、射频消融和肝移植;而B期和C期患者只能分别选择TACE和系统治疗。我国《原发性肝癌诊疗规范(2019年版)》将肝切除术的适应证从Ⅰa期扩展到Ⅲa期(BCLC分期A期到C期)。特别是部分具有高危复发因素的中晚期HCC纳入手术适应证后,其远期疗效不甚理想。

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