探究ICG荧光显影技术在腹腔镜肝细胞癌（肝癌）切除术中的临床应用安全性和疗效。

回顾性分析2023年1月至2024年1月在中山大学附属第三医院行腹腔镜肝癌切除术的患者47例患者临床资料。患者均签署知情同意书，符合医学伦理学规定。其中男40例，女7例；平均年龄（57±11）岁。根据是否采用ICG荧光显影技术，将患者分为ICG组（21例）和传统组（26例）。两组手术时间、术中出血量比较采用秩和检验，两组肿瘤切缘及术后并发症等比较采用χ²检验或Fisher确切概率法。

两组患者均在腹腔镜下完成肝癌切除术，无中转开腹。ICG组肿瘤切缘≥1 cm者16例，传统组7例，差异有统计学意义（χ²=11.284，P<0.05）。ICG组手术时间、术中出血量、术后住院时间分别为163（140，198）min、50（50，100）ml、4.0（4.0，5.5）d，传统组相应为170（134，226）min、50（28，100）ml、5.5（3.0，7.0）d，差异无统计学意义（Z=0.857，0.801，-1.083；P>0.05）。ICG组术后胆漏、腹腔积液分别为0、1例，传统组相应为4、0例，差异均无统计学意义（P>0.05）。

与传统腹腔镜肝癌切除术相比，ICG荧光显影技术能够帮助术者获得更理想的肿瘤切缘距离，且并未增加手术时间及手术风险。

To evaluate clinical efficacy and safety of ICG fluorescence imaging in laparoscopic hepatectomy of hepatocellular carcinoma (HCC).

Clinical data of 47 patients who underwent laparoscopic hepatectomy of HCC in the Third Affiliated Hospital of Sun Yat-sen University from January 2023 to January 2024 were retrospectively analyzed. The informed consents of all patients were obtained and the local ethical committee approval was received. Among them, 40 patients were male and 7 female, aged (57±11) years on average. All patients were divided into ICG group (n=21) and traditional group (n=26) according to whether ICG fluorescence imaging was used. Operation time and intraoperative blood loss between two groups were compared by rank-sum test. Tumor margin and the incidence of postoperative complications between two groups were compared by Chi-square test or Fisher’s exact test.

All HCC patients in two groups underwent laparoscopic hepatectomy without conversion to open surgery. In the ICG group, the tumor margin was ≥1 cm in 16 cases and 7 cases in the traditional group, and the difference was statistically significant (χ²=11.284, P<0.05). In the ICG group, the operation time, intraoperative blood loss and the length of postoperative hospital stay were 163 (140, 198) min, 50 (50, 100) ml and 4.0 (4.0, 5.5) d, respectively, compared with 170 (134, 226) min, 50 (28,100) ml and 5.5 (3.0,7.0) d in traditional group, and the differences were not statistically significant (Z=0.857, 0.801, -1.083; all P>0.05). In the ICG group, no postoperative bile leakage and 1 case of peritoneal effusion was observed, while 4 and 0 in the traditional group, and the difference was not statistically significant (both P>0.05).

Compared with traditional laparoscopic resection of HCC, ICG fluorescence imaging can assist surgeons to obtain more favorable tumor margin without prolonging operation time or increasing surgical risk.