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中华肝脏外科手术学电子杂志 ›› 2025, Vol. 14 ›› Issue (05) : 789 -794. doi: 10.3877/cma.j.issn.2095-3232.2025.05.020

综述

肝癌肺转移的放射治疗研究进展
丁雪吟1,2, 孙居仙2, 石洁2, 程树群1,2,()   
  1. 1 200437 上海中医药大学附属岳阳中西医结合医院肿瘤中心
    2 200438 上海,海军军医大学附属第三医院(上海东方肝胆外科医院)肝外六科
  • 收稿日期:2025-05-07 出版日期:2025-10-10
  • 通信作者: 程树群
  • 基金资助:
    国家重点研发计划项目(2022YFC2503700)

Research progress in radiotherapy for lung metastasis of hepatocellular carcinoma

Xueyin Ding1,2, Juxian Sun2, Jie Shi2, Shuqun Cheng,1,2()   

  1. 1 Department of Cancer Center, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China
    2 Department Ⅵ of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, the Third Affiliated Hospital of Naval Medical University, Shanghai 200438, China
  • Received:2025-05-07 Published:2025-10-10
  • Corresponding author: Shuqun Cheng
引用本文:

丁雪吟, 孙居仙, 石洁, 程树群. 肝癌肺转移的放射治疗研究进展[J/OL]. 中华肝脏外科手术学电子杂志, 2025, 14(05): 789-794.

Xueyin Ding, Juxian Sun, Jie Shi, Shuqun Cheng. Research progress in radiotherapy for lung metastasis of hepatocellular carcinoma[J/OL]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2025, 14(05): 789-794.

肝细胞癌(肝癌)是全球最常见的实体恶性肿瘤之一,肺是其最常见的转移部位。尽管肝癌早期发现和治疗可以改善预后,但许多患者在确诊时已出现远处转移,特别是肺转移。因此,肝癌肺转移的治疗逐渐成为研究热点。随着放疗技术的发展,针对肝癌肺转移开发出了多种新型的放射疗法,为提高疗效提供了更多可能。本综述将从内放射、外放射以及联合治疗的角度,总结和讨论近年来关于肝癌肺转移放射治疗的研究进展,包括预后因素、治疗效果和最新技术的应用。

Hepatocellular carcinoma (HCC) is one of the most common solid malignant tumors worldwide. Lung is the most common metastatic site of HCC. Although early diagnosis and treatment can improve clinical prognosis of HCC. However, a majority of HCC patients have been diagnosed with distant metastasis upon admission, especially lung metastasis. Therefore, the treatment of lung metastasis of HCC has gradually become a research hotspot. With the development of radiotherapy, multiple novel types of radiotherapy have been developed for lung metastasis of HCC, which provides more possibilities for enhancing efficacy. In this article, recent research progresses, including prognostic factors, therapeutic effect and application of the latest techniques, in radiotherapy for lung metastasis of HCC were reviewed and discussed from the perspectives of internal, external and combined radiotherapy, respectively.

表1 文献报道肝癌肺转移SABR疗效和不良反应
表2 文献报道肝癌肺转移常规放射治疗疗效和不良反应
表3 文献报道肝癌肺转移内放射治疗疗效和不良反应
表4 文献报道肝癌肺转移联合治疗疗效和不良反应
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