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中华肝脏外科手术学电子杂志

中华肝脏外科手术学电子杂志 ›› 2026, Vol. 15 ›› Issue (02) : 181 -189. doi: 10.3877/cma.j.issn.2095-3232.2026.02.007

前沿与争鸣

三维可视化技术、ICG荧光示踪和术中实时超声在肝癌个性化精准诊疗中应用
东小鸽1, 樊海宁2,3, 侯立朝2,3, 杜凯豪1, 刘海刚1, 汪占金1, 薛伟伟1, 石亚超1, 魏六木1, 王展2,3,4,†()   
  1. 1　810000　西宁，青海大学临床医学院
    2　810000　西宁，青海大学附属医院肝胆胰外科
    4　810000　西宁，青海大学附属医院医工结合与转化应用部
    3　810000　西宁，青海省包虫病研究重点实验室
  • 收稿日期:2025-08-10 出版日期:2026-04-10
  • 通信作者: 王展
  • 基金资助:
    国家自然科学基金(82160131); 中国科学院“西部之光”青年学者项目

Application of three-dimensional visualization technology, ICG fluorescence tracing and intraoperative real-time ultrasound in individualized precise diagnosis and treatment of liver cancer

Xiaoge Dong1, Haining Fan2,3, Lichao Hou2,3, Kaihao Du1, Haigang Liu1, Zhanjin Wang1, Weiwei Xue1, Yachao Shi1, Liumu Wei1, Zhan Wang2,3,4,†()   

  1. 1 Clinical Medical College of Qinghai University, Xining 810000, China
    2 Department of Hepatobiliary and Pancreatic Surgery, Qinghai University Affiliated Hospital, Xining 810000, China
    4 Department of Medical Engineering Integration and Translational Application, Qinghai University Affiliated Hospital, Xining 810000, China
    3 Key Laboratory of Hydatid Disease Research in Qinghai Province, Xining 810000, China
  • Received:2025-08-10 Published:2026-04-10
  • Corresponding author: Zhan Wang
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东小鸽, 樊海宁, 侯立朝, 杜凯豪, 刘海刚, 汪占金, 薛伟伟, 石亚超, 魏六木, 王展. 三维可视化技术、ICG荧光示踪和术中实时超声在肝癌个性化精准诊疗中应用[J/OL]. 中华肝脏外科手术学电子杂志, 2026, 15(02): 181-189.

Xiaoge Dong, Haining Fan, Lichao Hou, Kaihao Du, Haigang Liu, Zhanjin Wang, Weiwei Xue, Yachao Shi, Liumu Wei, Zhan Wang. Application of three-dimensional visualization technology, ICG fluorescence tracing and intraoperative real-time ultrasound in individualized precise diagnosis and treatment of liver cancer[J/OL]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2026, 15(02): 181-189.

近年来，三维可视化技术（3DVT）、ICG荧光示踪及术中实时超声（IORUS）在肝癌诊疗中的应用日益广泛，极大提升了肝癌早期诊断、定位、手术切除及术后监测的精准性。3DVT通过整合肝脏解剖结构和肿瘤信息，为外科医师提供了直观的术前评估和术中导航，有效降低了手术风险。作为一种安全高效的荧光染料，ICG可实时标记肿瘤的血供状态，辅助术者清晰识别肿瘤边界，提高了肿瘤切除的成功率。同时，IORUS凭借其高分辨率成像能力，实现了对肝脏病变的实时监控，确保了手术的精确性和安全性。3DVT、ICG荧光追踪与IORUS的应用为肝癌个性化诊疗提供了全新思路，推动了肝癌精准治疗的发展。本文对3DVT、ICG、IORUS在肝癌诊疗中的应用进行阐述，旨在为肝癌的临床诊疗提供新思路。

关键词: 癌，肝细胞, 三维可视化技术, 吲哚菁绿荧光示踪, 术中超声

In recent years, three-dimensional visualization technology (3DVT), ICG fluorescence tracing and intraoperative real-time ultrasound (IORUS) have been widely applied in the diagnosis and treatment of liver cancer, which significantly improve the accuracy of early diagnosis, localization, surgical resection and postoperative monitoring of liver cancer. 3DVT provides surgeons with intuitive preoperative evaluation and intraoperative navigation by integrating anatomical liver structures and tumor information, which effectively reduces the risk of surgery. As a safe and efficient fluorescent dye, ICG can mark the blood supply status of tumors in a real-time manner, assist the surgeons to clearly identify the tumor margins and improve the success rate of tumor resection. Due to high-resolution imaging capability, IORUS can realize real-time monitoring of liver lesions, ensuring the accuracy and safety of the operation. The application of 3DVT, ICG fluorescence tracing and IORUS provides novel ideas for individualized diagnosis and treatment of liver cancer and promotes the development of precise treatment of liver cancer. In this article, the application of 3DVT, ICG and IORUS in the diagnosis and treatment of liver cancer was illustrated, aiming to provide novel insights for clinical diagnosis and treatment of liver cancer.

Key words: Carcinoma,hepatocellular, Three-dimensional visualization technology, Indocyanine green fluorescence tracing, Intraoperative real-time ultrasound(IORUS)
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